Possible pathogenic role of endotoxin in Reye's syndrome.

A possible role for antibodies to tumour necrosis factor alpha and to endotoxin in the treatment of Reye's syndrome.

Is Reye's syndrome caused by augmented release of tumour necrosis factor?

Reye's syndrome affects children with a history of viral infection treated with aspirin. Its pathogenesis is unclear. Tumour necrosis factor (TNF) is released by macrophages activated by viral infection, endotoxin, and phagocytosis, and it has been shown to be a mediator of the toxic and metabolic effects of endotoxaemia. The metabolic effects of endotoxin and TNF are similar to those found in ...

Prior history of learning disabilities in Reye's syndrome survivors.

Twenty-six children, ages nine-18, who had recovered from Reye's syndrome were tested for possible memory deficits. In reviewing school histories, an unexpected finding was the disproportionately high number of students who were Learning Disabled before contracting Reye's syndrome. Seven of the children had been receiving special education services for being Learning Disabled and another two we...

Co-existence of hepatitis A and adult Reye's syndrome.

Reye's syndrome is most frequently seen in children but has also been described in adults. This syndrome is usually associated with ingestion of 5-aminosalicylates (ASA) or infection with influenza A, influenza B, or varicella virus. A case of Reye's syndrome in a 47 year old, previously healthy woman precipitated by ingestion of ASA and acute hepatitis A virus infection is described. Reye's sy...

Free fatty acids in an animal model of Reye's syndrome.

Recent studies have indicated that viral infections, aspirin treatment and hyperammonemia are associated with Reye's syndrome. It has also been reported that free fatty acids in serum and total lipids in the liver of Reye's syndrome patients are elevated during illness. The role of the lipid changes in the development of the disorder cannot be optimally studied in human patients, because infect...